Knowledge Synthesis and Application Unit
Active Projects
Insulin ruse for type 1 diabetes mellitus in adults, including emergency and humanitarian settings: a series of systematic reviews to inform WHO guidelines
These systematic reviews aim to inform the WHO guidelines for insulin use for type 1 diabetes mellitus in adults, including emergency settings. The reviews will specifically evaluate diagnosis, insulin types and regimens, as well as clinical and self-monitoring of glycaemic control.
Risk of bias concepts in vaccine effectiveness studies: A scoping review
Vaccine effectiveness (VE) studies are important to judge real-world effectiveness but are susceptible to biases. We conducted a scoping review to identify risk of bias (RoB) concepts in VE studies and examine their impact on VE estimates.
AGREE III: A tool for quality appraisal of living guidelines
The Appraisal of Guidelines for Research and Evaluation (AGREE) Instrument evaluates the process of practice guideline development and the quality of reporting. To improve the rigor and timeliness of practice guidelines, many have taken on a living approach, which the current iteration of the instrument (AGREE II) does not evaluate. This project aims to update the AGREE tool so that it can be used to properly evaluate the quality of living practice guidelines.
A living evidence approach to variants of concern (VOC) and COVID-19 vaccine effectiveness
Given the continued evolution of the pandemic, updated information is crucial for guiding policy decisions and prioritizing research efforts. This living review evaluates the effectiveness of WHO-approved COVID-19 vaccines (Pfizer–BioNTech, Moderna, Oxford–AstraZeneca, and Janssen) in protecting against Long Covid outcomes caused by variants of concern in adults.
Infection prevention and control measures for Ebola Virus and Marburg disease: A series of rapid systematic reviews
A series of rapid reviews were conducted to inform the updated 2023 World Health Organization (WHO) infection prevention and control (IPC) guideline for Ebola disease (EBOD) and Marburg disease (MARD)
Impact of post COVID-19 condition on the Canadian healthcare workforce: a living systematic review
Post-COVID-19 condition (PCC) is characterized as the continuation of symptoms past the acute clinical phase of infection. Although healthcare workers have increased risk of exposure to COVID-19, the prevalence of PCC and its wider impact on the healthcare workforce is unknown. Our objective was to investigate the prevalence of PCC in health care workers as well as the effect of PCC on work-related outcomes.